Contents

1. Mendalism and Mendalian Genetics

1. Introduction

1.1 Genetic Basis of Inheritance and Variations

1.2 Heredity

1.3 PreMendelian Concepts

1.4 Importance of Genetics

2. Mendel’s Experiments

2.1 Reasons for Mendel’s Success

3. Mendelian Laws

3.1 Law of Segregation

3.2 Monohybrid

4. Law of Independent Assortment

5. Deviation from Mendel’s Law

5.1 Partial or Incomplete Dominance

5.2 Co-dominance

5.3 Over Dominance

5.4 Epistasis

6. Penetrance and Expressivity

6.1 Pleiotropism

7. Gene Interaction

7.1 Modified Dihybrid Ratios

7.2 Characters of Multiple Alleles

7.3 Theories of Multiple Allelism

7.4 Segregation and Recombination of Multiple Alleles

2. Chromosomal Aberrations and mutations

1. Introduction

2. Variation in Chromosome Number

2.1 Euploidy

2.2  Aneuploidy

3. Dosage Compensation and Barr Bodies

3.1 Dosage Compensation

3.2 Barr Bodies

4. Variation in Chromosome Structure

4.1 Variation in the Arrangement of Chromosome Segments

4.2 Generation of Variations

5. Mutations

5.1 Classification and Types

5.2 The Molecular Basis of Mutation

6. Mutagens and their Action

6.1 Radiation Induced Mutation

6.2  Chemically Induced Mutation

6.3 Hot Spot Mutations

3. Sex Determination and Recombination

1.  Linkage and Recombination

2. What is Linkage?

2.2 The Discovery of Linkage

3. Complete and Incomplete Linkage

3.1 Complete Linkage

3.2 Incomplete Linkage

3.3 Crossing Over

3.4 Types of Cross Over

3.5 Map Distance

4. Mechanism of Sex Determination

4.1 Homo and Heterogametic Theory

4.2 Coincidence and Interference

4.3 X Linked Inheritance

4.4 Non Mendelian Inheritance

5. Pedigree Analysis

5.1 Standard Symbols

4. Genetic Disorders

1. Introduction

1.1 Sickle Cell Anemia

1.2 Hemophilia

1.3 Colour Blindness

1.4 Albinism

1.5 Down’s Syndrome

1.6 Kleinfelters Syndrome

2. Genetic Counseling